Impact of the longitudinal changes of myocardial remodeling on cardiovascular outcomes of kidney transplantation recipients

Abstract Funding Acknowledgements Type of funding sources: None. Background Kidney transplantation (KT) improves the hemodynamic burden associated with volume overload, and anemia in patients chronic kidney disease, but cardiovascular disease remains leading cause death after KT. This study evaluated longitudinal change eccentric concentric myocardial remodeling its impact on outcomes Methods A total 600 who underwent echocardiography before 3 years KT were included from a multi-center observational cohort (KNOW-KT). Conventional echocardiograph left ventricular ejection fraction (LV EF), LV mass index (LVMI) end-diastolic dimension (LVEDD), relative wall thickness (RWT) at baseline KT, changes these parameters their effect events investigated. Results After EF, LVMI, eccentricity represented by LVEDD significantly improved for EF; 61.4±7.9 to 64.8±6.0 %, LVMI; 113.4 ± 31.8 94.4 23.4 g/m2, LVEDD; 51.2 5.6 47.1 4.8 mm), however, concentricity RWT increased 0.39 0.07 0.41 0.07. The proportion compared (Figure 1). In correlation analysis between echocardiographic clinical parameters, was stress such as hemoglobin or systolic blood pressure, whereas showed significant association metabolic HbA1c triglycerides. There 30 major adverse (MACE, infarction, angina, strokes) incidence MACE group, not group 2). multivariate corrected age, sex, diabetes, etc., an increase RWT, independently predicted occurrence (HR 2.20 CI 1.21–3.99, p<0.01), other including LVEF, did not. Conclusions Longitudinal is have new onset patients. Improving should be considered important strategy amelioration cardiac event.